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소속: 생명과학대학 해양바이오식품학과

전화번호: 033-640-2343

이메일: choi.kiyoung@gwnu.ac.kr

연구분야: 식의약품 나노/마이크로 제제 연구

세부내용

학력

경희대학교 환경응용화학부 학사
경희대학교 나노의약생명과학과 석·박사

경력

2023.03 ~ 현재: 강릉원주대 생명과학대학 해양식품공학과 조교수
2021.03 ~ 2023.02: 과학기술연합대학원대학교 (UST) 부교수
2018.09 ~ 2023.02: 한국과학기술연구원 (KIST) 선임연구원
2018.04 ~ 2018.08: 서울대학교 연구조교수
2015.11 ~ 2018.03: 성균관대학교 연구교수
2014.02 ~ 2016.04: Massachusetts Institute of Technology (MIT) 박사 후 연구원
2011.08 ~ 2014.02: National Institutes of Health (NIH) 박사 후 연구원
2010.08 ~ 2011.07: Purdue University / Weldon School of Biomedical Engineering 방문연구원

전문연구분야

Extracellular nanovesicles for treatment of intractable diseases
Nano/micro formulation of bioactive compounds
Gene and drug delivery nanosystems
Nano-bio imaging toolbox

주요논문

1. Plant-derived nanovesicles: Current understanding and applications for cancer therapy. Bioactive Materials. 2023; 22: 365. (https://www.sciencedirect.com/science/article/pii/S2452199X22004297?via%3Dihub)
2. Crystallinity-tuned ultrasoft polymeric DNA networks for controlled release of anticancer drugs. J Control Release. 2023; 355: 7. (https://www.sciencedirect.com/science/article/pii/S0168365923000652?via%3Dihub)
3. Nanoencapsulation enhances the bioavailability of fucoxanthin in microalga Phaeodactylum tricornutum extract. Food Chem. 2023; 403: 134348. (https://www.sciencedirect.com/science/article/pii/S030881462202310X?via%3Dihub)
4. Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging. Bioactive Materials. 2022; 14: 182. (https://www.sciencedirect.com/science/article/pii/S2452199X21005594?via%3Dihub)
5. Schisandrin C improves leaky gut conditions in intestinal cell monolayer, organoid, and nematode models by increasing tight junction protein e-x-p-r-e-s-s-i-o-n. Phytomedicine. 2022; 103: 154209. (https://www.sciencedirect.com/science/article/pii/S0944711322002872)
6. Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells. Biomacromolecules. 2022; 23: 2255-63. (https://pubs.acs.org/doi/abs/10.1021/acs.biomac.1c01497)
7. Discovery and Photoisomerization of New Pyrrolosesquiterpenoids Glaciapyrroles D and E, from Deep-Sea Sediment Streptomyces sp. Marine Drugs. 2022. 20 (5), 281. (https://www.mdpi.com/1660-3397/20/5/281)
8. Advances in Nanomaterial-Mediated Photothermal Cancer Therapies: Toward Clinical Applications. Biomedicines. 2021; 9: 305. (https://www.mdpi.com/2227-9059/9/3/305)
9. 2D to 3D transformation of gold nanosheets on human adipose-derived α-elastin nanotemplates. Journal of Industrial and Engineering Chemistry. 2021; 95, 66-72. (https://www.sciencedirect.com/science/article/pii/S1226086X20305402)
10. Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells. Chem Commun (Camb). 2020; 56: 6624-7. (https://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc01848a#!divAbstract)
11. Human adipose stem cell-derived extracellular nanovesicles for treatment of chronic liver fibrosis. J Control Release. 2020. (https://www.sciencedirect.com/science/article/pii/S0168365920300614)
12. Hyaluronic Acid-Based Activatable Nanomaterials for Stimuli-Responsive Imaging and Therapeutics: beyond CD44-Mediated Drug Delivery. Adv Mater. 2019; 31: 1803549. (https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201803549)
13. Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo using Layer-by-Layer Nanoparticles. Adv Funct Mater. 2019; 29: 1900018. (https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201900018)
14. Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery. Chem Commun (Camb). 2019; 55, 4905-8. (https://pubs.rsc.org/en/content/articlehtml/2019/cc/c9cc01442j)
15. Control of a toxic cyanobacterial bloom species, Microcystis aeruginosa, using the peptide HPA3NT3-A2. Environmental Science and Pollution Research. 2019; 26: 32255-65. (https://link.springer.com/article/10.1007/s11356-019-06306-4)
16. Intracellularly Activatable Nanovasodilators to Enhance Passive Cancer Targeting Regime. Nano Lett. 2018; 18: 2637-44. https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.8b00495)
17. Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis. Biomaterials. 2017; 131: 15-26. (https://www.sciencedirect.com/science/article/pii/S0142961217302016)
18. Gold-Nanoclustered Hyaluronan Nano-Assemblies for Photothermally Maneuvered Photodynamic Tumor Ablation. ACS Nano. 2016; 10: 10858-10868. (https://pubs.acs.org/doi/abs/10.1021/acsnano.6b05113)
19. Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer. Nano Lett. 2016; 16: 6257-64. (https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.6b02547)
20. Designer Dual Therapy Nanolayered Implant Coatings Eradicate Biofilms and Accelerate Bone Tissue Repair. ACS Nano. 2016; 10: 4441-4450 (https://pubs.acs.org/doi/abs/10.1021/acsnano.6b00087)
21. Bioreducible Core-Crosslinked Hyaluronic Acid Micelle for Targeted Cancer Therapy. J Control Release. 2015; 200: 158-66. (https://www.sciencedirect.com/science/article/pii/S0168365914008293)
22. Highly scalable, closed-loop synthesis of drug-loaded, layer-by-layer nanoparticles. Adv Funct Mater. 2015; 26: 991-1003 (https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201504385)
23. Tumor-Targeted Synergistic Blockade of MAPK and PI3K From a Layer-by-Layer Nanoparticle. Clin Cancer Res. 2015; 21: 4410-19 (https://clincancerres.aacrjournals.org/content/21/19/4410.short)
24. Hyaluronic acid nanoparticles for active targeting atherosclerosis. Biomaterials. 2015; 53: 341-8. (https://www.sciencedirect.com/science/article/pii/S0142961215002197)
25. Bioreducible Shell-Cross-Linked Hyaluronic Acid Nanoparticles for Tumor-Targeted Drug Delivery. Biomacromolecules. 2015; 16: 447-56. (https://pubs.acs.org/doi/abs/10.1021/bm5017755)
26. Inhibition of Notch signalling ameliorates experimental inflammatory arthritis. Ann Rheum Dis. 2015; 74: 267-74. (https://ard.bmj.com/content/74/1/267.short)
27. A nanoparticle formula for delivering siRNA or miRNAs to tumor cells in cell culture and in vivo. Nat Protoc. 2014; 9: 1900-15. (https://www.nature.com/articles/nprot.2014.128)
28. Versatile RNA-Interference Nanoplatform for Systemic Delivery of RNAs. ACS Nano. 2014; 8: 4559-70. (https://pubs.acs.org/doi/abs/10.1021/nn500085k)
29. Design Considerations of Iron-Based Nanoclusters for Noninvasive Tracking of Mesenchymal Stem Cell Homing. ACS Nano. 2014; 8: 4403-14. (https://pubs.acs.org/doi/abs/10.1021/nn4062726)
30. The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development. Biomaterials. 2014; 35: 856-65. (https://www.sciencedirect.com/science/article/pii/S014296121301257X)
31. Bioreducible Carboxymethyl Dextran Nanoparticles for Tumor-Targeted Drug Delivery. Adv Healthc Mater. 2014; 3: 1829-38. (IF: 6.270) (https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201300691)
32. Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots. ACS Nano. 2013; 7: 5684-93. (https://pubs.acs.org/doi/abs/10.1021/nn401911k)
33. Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery. Biomaterials. 2013; 34: 1772-80. (https://www.sciencedirect.com/science/article/pii/S0142961212012914)
34. Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery. Biomaterials. 2013; 34: 5273-80. (https://www.sciencedirect.com/science/article/pii/S0142961213003608)
35. Self-assembled dextran sulphate nanoparticles for targeting rheumatoid arthritis. Chem Commun (Camb). 2013; 49: 10349-51. (https://pubs.rsc.org/en/content/articlehtml/2013/cc/c3cc44260h)
36. Bibliometric analysis of theranostics: two years in the making. Theranostics. 2013; 3: 527-31. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706696/)
37. A Facile, One-Step Nanocarbon Functionalization for Biomedical Applications. Nano Lett. 2012; 12: 3613-20. (https://pubs.acs.org/doi/abs/10.1021/nl301309g)
38. Sticky Nanoparticles: A New Platform for siRNA Delivery by Bis(Zinc(II)-Dipicolyamine)-Functionalized, Self-Assembled Nanoconjugate. Angew Chem Int Ed Engl. 2012; 51: 445-9. (https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201105565)
39. Theranostic nanoparticles based on PEGylated hyaluronic acid for the diagnosis, therapy and monitoring of colon cancer. Biomaterials. 2012; 33: 6186-93. (https://www.sciencedirect.com/science/article/pii/S0142961212005583)
40. Protease-Activated Drug Development. Theranostics. 2012; 2: 156-78. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296471/)
41. Theranostic Nanoplatforms for Simultaneous Cancer Imaging and Therapy: Current Approaches and Future Perspectives. Nanoscale. 2012; 4: 330-42. (https://pubs.rsc.org/en/content/articlehtml/2012/nr/c1nr11277e)
42. Hyaluronic Acid-Based Nanocarriers for Intracellular Targeting: Interfacial Interactions with Proteins in Cancer. Colloid Surface B. 2012; 99: 82-94. (https://www.sciencedirect.com/science/article/pii/S0927776511006138)
43. Multiplex Imaging of an Intracellular Proteolytic Cascade by Using a Broad-Spectrum Nanoquencher. Angew Chem Int Ed Engl. 2012; 51: 1625-30. (https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201107795)
44. Tumor-Targeting Hyaluronic Acid Nanoparticles for Photodynamic Imaging and Therapy. Biomaterials. 2012; 33: 3980-9. (https://www.sciencedirect.com/science/article/pii/S0142961212001822)
45. Real-Time Monitoring of Caspase Cascade Activation in Living Cells. J Control Release. 2012; 163: 55-62. (https://www.sciencedirect.com/science/article/pii/S0168365912004579)
46. Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues. J Control Release. 2012; 157:493-9. (https://www.sciencedirect.com/science/article/pii/S0168365911008558)
47. Amphiphilic Hyaluronic Acid-Based Nanoparticles for Tumor-Specific Optical/Mr Dual Imaging. J Mater Chem. 2012; 22: 10444-7. (https://pubs.rsc.org/en/content/articlehtml/2012/jm/c2jm31406a)
48. Site-specific PEGylated Exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects. Bioconjug Chem. 2012; 23: 2214-20. (https://pubs.acs.org/doi/abs/10.1021/bc300265n)
49. Smart Nanocarrier Based on PEGylated Hyaluronic Acid Nanoparticles for Cancer Therapy. ACS Nano. 2011; 5: 8591-9. (https://pubs.acs.org/doi/abs/10.1021/nn202070n)
50. Real time, high resolution video imaging of apoptosis in singly cells with a polymeric nanoprobe, Bioconjugate Chem. 2011; 22: 125-31. (https://pubs.acs.org/doi/abs/10.1021/bc1004119)
51. PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo, Biomaterials. 2011; 32: 1880-9. (https://www.sciencedirect.com/science/article/pii/S0142961210014328)
52. Manipulating the Power of an Additional Phase: A Flower-like Au-Fe(3)O(4) Optical Nanosensor for Imaging Protease e-x-p-r-e-s-s-i-o-ns In vivo, ACS Nano. 2011; 5: 3043-51. (https://pubs.acs.org/doi/abs/10.1021/nn200161v)
53. Self-assembled hyaluronic acid nanoparticles for active tumor targeting, Biomaterials. 2010; 31: 106-14. (https://www.sciencedirect.com/science/article/pii/S0142961209009600)
54. Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis, Biomaterials. 2010; 31: 9057-64. (https://www.sciencedirect.com/science/article/pii/S0142961210010215)
55. Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel, Int J Pharm. 2010; 394: 154-61. (https://www.sciencedirect.com/science/article/pii/S0378517310003133)
56. Self-assembled hyaluronic acid nanoparticles as potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution. J Mater Chem. 2009; 19: 4102-7. (https://pubs.rsc.org/en/content/articlehtml/2009/jm/b900456d)
57. Preparation and characterization of hyaluronic acid-based hydrogel nanoparticles, J Phys Chem Solids. 2008; 69: 1591-5. (https://www.sciencedirect.com/science/article/pii/S0022369707006397)